Related Experiment Video
Updated: Nov 24, 2025
04:25
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
10.6K
Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs
Chenglong Chen1, Lu Xie2, Tingting Ren1
1Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, People's Republic of China; Beijing Key Laboratory of Musculoskeletal Tumor, Beijing, People's Republic of China.
Cancer Letters
|December 28, 2020
Summary
Osteosarcoma immunotherapy shows promise for treating bone cancer, even in advanced stages. Recent advances in immune response understanding and biomarker development are paving the way for new treatments.
Area of Science:
- Oncology
- Immunology
- Bone Cancer Research
Background:
- Osteosarcoma (OS) is the most common primary bone cancer.
- Metastatic or recurrent OS has a poor prognosis despite surgery and chemotherapy.
- Immunotherapy offers a promising strategy for treating various cancers.
Purpose of the Study:
- To review recent advances in osteosarcoma immunotherapy.
- To discuss the mechanisms and current status of OS immunotherapies.
- To explore future therapeutic directions for osteosarcoma.
Main Methods:
- Literature review of preclinical and clinical studies on osteosarcoma immunotherapy.
- Analysis of immune response mechanisms in osteosarcoma.
- Examination of biomarker development in OS immunotherapy.
Main Results:
- Immunotherapy is a rapidly advancing field for osteosarcoma treatment.
- Improved understanding of immune responses and biomarkers enhances patient benefit.
- Preclinical and clinical trials show potential for novel immunotherapeutic approaches.
Conclusions:
- Recent advances in immunotherapy hold significant promise for osteosarcoma patients.
- Further research into immune mechanisms and biomarkers is crucial.
- Novel immunotherapies may offer new hope for patients with advanced or recurrent osteosarcoma.
Related Concept Videos
01:27Tumor Immunotherapy
880
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
880
02:49Cancer Therapies
9.1K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.1K
02:57Targeted Cancer Therapies
8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.1K
01:30Cancer Vaccines
630
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
630
02:56Treatment Resistant Cancers
3.5K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.5K
02:50Combination Therapies and Personalized Medicine
5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K