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Elevated C-reactive protein is significantly associated with left ventricular dysfunction in patients with aortic

Hiroki Usuku1, Eiichiro Yamamoto2, Momoko Noguchi3

  • 1Department of Laboratory Medicine, Kumamoto University Hospital, Kumamoto, Japan; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences, Kumamoto, Japan.

International Journal of Cardiology
|December 28, 2020
PubMed

Insights

High C-reactive protein (CRP) levels indicate uncontrolled inflammation and are a significant risk factor for left ventricular (LV) dysfunction in patients with aortic regurgitation (AR) and collagen disease.

Area of Science:

  • Cardiology
  • Rheumatology
  • Internal Medicine

Background:

  • Collagen diseases are a significant cause of aortic regurgitation (AR).
  • Left ventricular (LV) dysfunction is a concern in AR patients, especially those with collagen disease.
  • Risk factors for LV dysfunction in AR patients with collagen disease are not well-established.

Purpose of the Study:

  • To identify risk factors for left ventricular (LV) dysfunction in patients with moderate to severe aortic regurgitation (AR) and concomitant collagen disease.
  • To investigate the association between inflammation markers and LV dysfunction in this patient cohort.

Main Methods:

  • A retrospective study of 41 patients with AR and collagen disease at Kumamoto University Hospital (January 2014 - December 2019).
  • Comparison of baseline characteristics, inflammatory markers (CRP, neutrophil-to-lymphocyte ratio), and hemoglobin levels between patients with preserved and reduced LV function.
  • Multivariable logistic regression analysis to determine independent predictors of LV dysfunction.

Main Results:

  • Patients with reduced LV function had significantly higher B-type natriuretic peptide, C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio, and lower hemoglobin levels compared to those with preserved LV function.
  • No significant differences were observed in collagen disease type or AR severity between the groups.
  • High CRP levels (≥1.0 mg/dl) were independently and significantly associated with LV dysfunction (odds ratio: 95.7, p < 0.01).

Conclusions:

  • Uncontrolled inflammation, indicated by elevated CRP levels, is a crucial marker for LV dysfunction in patients with AR and collagen disease.
  • CRP levels serve as an important predictor of LV dysfunction in this specific patient population.
  • Managing inflammation may be key in preventing or mitigating LV dysfunction in AR patients with collagen disease.
Abstract

Keywords:
Aortic regurgitationCollagen diseaseLeft ventricular dysfunction

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