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Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase
Chun Lei1, Xiao-Hang Wang1, Yi-Nan Liu2
1School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201203, China.
Abstract:
Six undescribed clerodane diterpenoids, dodovisins A-F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD calculation. Dodovisins A and B possess a rare carbon skeleton featuring a bicyclo[6.2.0]decane motif. Dodovisins C-E represent the first clerodane diterpenoids with a 4(5 → 19)-abeo-2,4,10(1)-triene moiety. Dodovisins A, E, and strictic acid showed potent inhibitory activities against ATP citrate lyase.
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