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Role of lncRNA LUCAT1 in cancer

Ce Xing1, Shou-Gang Sun1, Zhi-Quan Yue1

  • 1Lanzhou University Second Hospital, Department of Cardiology, 82 Cuiying Men, Lanzhou, 730030, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 28, 2020
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate gene expression and are implicated in cancer development. The lung cancer-related transcript 1 (LUCAT1) is a key player in various malignancies, acting as a potential biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression at epigenetic, transcriptional, post-transcriptional, and translational levels.
  • Dysregulation of lncRNAs is linked to tumor suppressor or carcinogenic effects, impacting tumor development.
  • Lung cancer-related transcript 1 (LUCAT1), identified in smoking-related lung cancer, is implicated in multiple cancers.

Purpose of the Study:

  • To review the expression, function, and molecular mechanisms of LUCAT1 in various malignant tumors.
  • To highlight LUCAT1's role in tumor proliferation, invasion, and migration.
  • To establish LUCAT1 as a potential prognostic biomarker and therapeutic target for cancer.

Main Methods:

  • Literature review of studies on LUCAT1 expression and function in cancer.
  • Analysis of LUCAT1's molecular mechanisms in regulating tumor progression.
  • Correlation analysis of LUCAT1 with clinicopathological characteristics.

Main Results:

  • LUCAT1 is highly expressed in liver cancer and other malignant tumors, inducing various cancers.
  • LUCAT1 influences tumor proliferation, invasion, and migration through diverse mechanisms.
  • LUCAT1 expression correlates with clinicopathological features of cancer patients.

Conclusions:

  • LUCAT1 is a significant oncogenic lncRNA involved in the development and progression of multiple cancers.
  • LUCAT1 exhibits potential as a prognostic biomarker and a therapeutic target for cancer treatment.
  • Further research into LUCAT1's mechanisms can inform novel cancer therapies.
Keywords:
CancersLUCAT1LncRNAMolecular mechanisms

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