Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke
Manabu Ishihara1, Nobuto Nakanishi2, Rie Tsutsumi3
1Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University, 2-50-1 Kuramoto, Tokushima 770-8503, Japan.
Summary
Urinary titin levels rise quickly after stroke and correlate with poorer functional outcomes. This study provides the first clinical data on urinary titin in stroke patients, highlighting its potential as a biomarker.
Area of Science:
- Biochemistry
- Neurology
- Biomarkers
Background:
- Urinary titin is a known biomarker for muscle atrophy.
- Muscle atrophy is a significant complication following stroke.
- Clinical data on urinary titin in stroke patients are currently lacking.
Purpose of the Study:
- To investigate the trend of urinary titin levels in acute stroke patients.
- To assess the association between peak urinary titin levels and functional outcomes post-stroke.
Main Methods:
- Consecutive stroke patients were enrolled, with urine samples collected on days 1, 3, 5, and 7 post-admission.
- Peak urinary titin levels were correlated with modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), and Barthel Index (BI) at discharge.
- Multivariate analysis was performed to predict poor outcome (mRS 3-6) using peak urinary titin, adjusted for demographic and clinical factors.
Main Results:
- Forty-one stroke patients (mean age 68 years) were included.
- Urinary titin levels showed a rapid increase after stroke, peaking by day 3.
- Peak urinary titin levels significantly correlated with mRS (r=0.55), NIHSS (r=0.72), and BI (r=-0.59) at discharge (p<0.01 for all).
Conclusions:
- Urinary titin levels increase rapidly in the acute phase after stroke.
- Elevated peak urinary titin is associated with worse functional outcomes at hospital discharge.
- Urinary titin shows potential as a predictive biomarker for stroke recovery.
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