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Updated: Nov 24, 2025

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Rotational spectrum and internal dynamics of the hydrogen-bonded pyrrole-pyridine aromatic pair
Carlos Cabezas1, Isabel Peña2, Walther Caminati3
1Instituto de Física Fundamental (IFF-CSIC), Group of Molecular Astrophysics, C/Serrano 121, 28006 Madrid, Spain.
Abstract:
Non-covalent interactions determine the three-dimensional structure and activity of biological molecules. In this work, the pyrrole-pyridine complex considered as a model of the NH⋯N hydrogen-bonded Watson-Crick base pairs has been generated in a supersonic expansion and characterized by chirped pulse Fourier transform microwave spectroscopy. The analysis of the unconventional spectral pattern of the 1:1 pyrrole-pyridine adduct and its 13C and 15N isotopologues reveal a non-planar complex, with a bent NH⋯N hydrogen bond and large amplitude motion of the pyrrole subunit. The bent structure is likely to arise from the stablishment of the secondary CH⋯N interaction between pyridine and pyrrole moieties.
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