A link between long non-coding RNA (lncRNA) and thalassaemia: A review

Area of Science:

• Molecular Biology
• Genetics
• RNA Biology

Background:

• Long non-coding RNAs (lncRNAs) are a diverse class of non-coding RNA molecules.
• Initially considered transcriptional noise, lncRNAs are increasingly recognized for their regulatory roles in cellular processes.
• Emerging evidence links lncRNA dysregulation to various human diseases.

Purpose of the Study:

• To review the current understanding of long non-coding RNAs.
• To explore the potential involvement of dysregulated lncRNAs in the pathogenesis of thalassaemia.
• To highlight knowledge gaps regarding lncRNA function in thalassaemia.

Main Methods:

• Literature review of studies on lncRNAs and thalassaemia.
• Analysis of existing research on lncRNA functions in physiological and pathological conditions.
• Synthesis of information to propose roles for lncRNAs in thalassaemia pathogenesis.

Main Results:

• lncRNAs play critical roles in various physiological processes, including haemopoiesis.
• Dysregulation of specific lncRNAs has been observed in different disease contexts.
• The specific contributions of lncRNAs to thalassaemia pathogenesis remain largely under-investigated.

Conclusions:

• Dysregulated lncRNAs may represent a significant factor in the pathogenesis of thalassaemia.
• Further research is warranted to elucidate the precise mechanisms by which lncRNAs influence thalassaemia.
• Targeting lncRNAs could offer novel therapeutic strategies for thalassaemia.