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Related Experiment Video

Updated: Nov 24, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

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Nociceptive nerves regulate haematopoietic stem cell mobilization.

Xin Gao^1,2, Dachuan Zhang^1,2, Chunliang Xu^1,2

¹Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.

|December 28, 2020

Summary

Nociceptive nerves, not just sympathetic ones, are crucial for hematopoietic stem cell (HSC) mobilization. These nerves release calcitonin gene-related peptide (CGRP), directly promoting HSCs to leave the bone marrow.

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Area of Science:

Hematology
Neuroscience
Stem Cell Biology

Background:

Hematopoietic stem cells (HSCs) reside in specialized bone marrow niches.
Sympathetic nerves influence HSC niches, but the role of nociceptive neurons is unknown.

Purpose of the Study:

To investigate the role of nociceptive neurons in HSC mobilization and maintenance within the bone marrow niche.

Main Methods:

Investigated HSC mobilization in response to nociceptive nerve activity.
Analyzed the molecular mechanisms of HSC egress driven by nociceptor-derived factors.
Examined the direct effects of CGRP on HSCs.

Main Results:

Nociceptive nerves are essential for enforced HSC mobilization, collaborating with sympathetic nerves.
Nociceptors drive G-CSF-induced HSC mobilization via CGRP secretion.
CGRP directly acts on HSCs through RAMP1 and CALCRL, promoting egress via the Gαs/adenylyl cyclase/cAMP pathway.
Capsaicin ingestion enhanced HSC mobilization in mice.

Conclusions:

Nociceptive neurons play a critical role in HSC mobilization.
Targeting the nociceptive nervous system may enhance HSC yield for therapeutic applications.