Both speckle reduction and contrast enhancement for optical coherence tomography via sequential optimization in the...

Optical coherence tomography (OCT) image enhancement is a challenging task because speckle reduction and contrast enhancement need to be addressed simultaneously and effectively. We present a refined Retinex model for guidance in improving the performance of enhancing OCT images accompanied by speckle noise; a physical explanation is provided. Based on this model, we establish two sequential optimization functions in the logarithmic domain for speckle reduction and contrast enhancement, respectively. More specifically, we obtain the despeckled image of an entire OCT image by solving the first optimization function. Incidentally, we can recover the speckle noise map through removing the despeckle component directly. Then, we estimate the illumination and reflectance by solving the second optimization function. Further, we apply the contrast-limited adaptive histogram equalization algorithm to adjust the illumination, and project it back to the reflectance for achieving contrast enhancement. Experimental results demonstrate the robustness and effectiveness of our proposed method. It performs well in both speckle reduction and contrast enhancement and is superior to the other two methods both in terms of qualitative analysis and quantitative assessment. Our method has the practical potential to improve the accuracy of manual screening and computer-aided diagnosis for retinal diseases.