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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Mode-splitting in a microring resonator for self-referenced biosensing.

M de Goede, M Dijkstra, L Chang

    Optics Express
    |December 28, 2020
    PubMed
    Summary

    This study demonstrates a self-referenced biosensor using mode-splitting in microring resonators. It accurately detects biomolecules by measuring changes in grating reflectivity, unaffected by environmental shifts.

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    Area of Science:

    • Photonics and Sensing
    • Integrated Optics
    • Biotechnology

    Background:

    • Microring resonators are sensitive to their environment.
    • Mode-splitting in resonators offers a potential sensing mechanism.
    • Existing biosensors often suffer from environmental interference.

    Purpose of the Study:

    • To demonstrate a self-referenced biosensing approach using mode-splitting.
    • To develop a biosensor insensitive to temperature and refractive index variations.
    • To integrate a Bragg grating onto a microring resonator for enhanced sensing.

    Main Methods:

    • Experimental demonstration of self-referenced biosensing.
    • Integration of a polymethyl methacrylate (PMMA) Bragg grating onto an Al2O3 microring resonator.
    • Theoretical and experimental analysis of mode-splitting variations under different conditions.

    Main Results:

    • Mode-splitting is primarily affected by structural changes to the Bragg grating.
    • Environmental perturbations (temperature, refractive index) have minimal impact on mode-splitting.
    • Attachment of biomolecules to the grating alters reflectivity and mode-splitting, enabling detection.

    Conclusions:

    • The study presents the first proof-of-concept for an integrated mode-splitting biosensor.
    • This biosensor is insensitive to temperature and refractive index fluctuations.
    • The developed technology paves the way for robust, self-referenced biosensing applications.