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Updated: Nov 24, 2025
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Development of an efficient, one-pot, multicomponent protocol for synthesis of
Rukhsana Tabassum1, Muhammad Ashfaq1, Hiroyuki Oku2
1Department of Chemistry The Islamia University of Bahawalpur Bahawalpur Pakistan.
Abstract:
A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol run smoothly to give variety of quinoline derivatives in 55% to 98% yield from inexpensive reagents and catalyst in mild reaction conditions. Various spectroscopic techniques like FTIR, 1H NMR and 13C NMR, MALDI-TOF-MS, and EI-MS were used to study and confirm their structure.
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