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Menstrual cycle effect on plasma lipids.

D Y Jones1, J T Judd, P R Taylor

  • 1National Cancer Institute, NIH, Bethesda, MD 20892-4200.

Metabolism: Clinical and Experimental
|January 1, 1988
PubMed
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Plasma cholesterol levels in women fluctuate during the menstrual cycle. Cholesterol was significantly higher in the follicular phase compared to the luteal phase, indicating hormonal influences on lipid profiles.

Area of Science:

  • Reproductive Endocrinology
  • Lipid Metabolism
  • Human Physiology

Background:

  • Menstrual cycle phases are associated with hormonal fluctuations.
  • Hormonal changes can impact various physiological markers, including lipid profiles.
  • Understanding these variations is crucial for accurate health assessments.

Purpose of the Study:

  • To investigate the impact of the menstrual cycle on plasma lipid levels in healthy women.
  • To determine if plasma cholesterol, triglycerides, and HDL-cholesterol differ significantly between the follicular and luteal phases.
  • To control for dietary intake and body weight to isolate the effect of the menstrual cycle.

Main Methods:

  • A controlled study involving 31 healthy women.
  • Dietary intake and body weight were strictly controlled throughout the study.

Related Experiment Videos

  • Plasma samples were analyzed to compare lipid levels during the follicular and luteal phases.

    • Main Results:

    • Significantly higher mean plasma cholesterol in the follicular phase (8.4% difference) compared to the luteal phase.
    • A trend towards higher mean plasma triglycerides (7.4% difference) and lower HDL-cholesterol (5.8% difference) in the follicular phase.
    • These triglyceride and HDL-cholesterol differences were not consistently significant across all measurements.

    Conclusions:

    • Plasma cholesterol levels exhibit significant variation across the menstrual cycle in healthy women.
    • Hormonal shifts during the menstrual cycle may influence lipid metabolism.
    • Further research is warranted to confirm the significance of triglyceride and HDL-cholesterol changes.