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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Nov 24, 2025

In Vitro Assay to Study Tumor-macrophage Interaction
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Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy.

Zhong-Wei Luo1,2, Pan-Pan Liu3, Zhen-Xing Wang1,2

  • 1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Oncology
|December 28, 2020
PubMed
Summary

Osteosarcoma treatment needs improvement, especially for recurrent cases. Targeting tumor-infiltrating macrophages within the tumor microenvironment (TME) offers a promising new immunotherapy strategy for osteosarcoma patients.

Keywords:
immunotherapymacrophagesosteosarcomatumor microenvironmenttumor-associated macrophages (TAMs)

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Osteosarcoma is a primary bone cancer affecting children and adolescents, with stagnant survival rates for recurrent or metastatic disease.
  • The tumor microenvironment (TME) significantly influences tumor development, with macrophages being key immune cells within it.
  • Macrophages play critical roles in tumor progression, making them a focus for novel cancer immunotherapies.

Purpose of the Study:

  • To review the role of macrophages in the osteosarcoma tumor microenvironment (TME).
  • To highlight the clinical significance and involvement of macrophages in osteosarcoma initiation and progression.
  • To summarize macrophage-targeting therapeutic strategies for osteosarcoma.

Main Methods:

  • Literature review of scientific articles on osteosarcoma, tumor microenvironment, macrophages, and immunotherapy.
  • Analysis of the role of macrophages in osteosarcoma pathogenesis.
  • Summary of current and emerging therapeutic approaches targeting macrophages in osteosarcoma.

Main Results:

  • Macrophages are abundant in the osteosarcoma TME and influence tumor progression.
  • Understanding macrophage functions in osteosarcoma is crucial for developing effective treatments.
  • Targeting macrophages presents a promising avenue for improving osteosarcoma patient outcomes.

Conclusions:

  • Macrophages are critical players in osteosarcoma development and progression.
  • Therapeutic strategies focused on modulating macrophages in the TME show potential for treating osteosarcoma.
  • Targeting macrophages represents a promising immunotherapy approach for osteosarcoma, particularly in advanced stages.