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Related Experiment Video

Updated: Nov 24, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

9.7K

Building Scaffolds for Tubular Tissue Engineering.

Alexander J Boys1, Sarah L Barron1, Damyan Tilev1

  • 1Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.

Frontiers in Bioengineering and Biotechnology
|December 28, 2020
PubMed
Summary

This review covers tissue engineering methods for tubular organs like blood vessels, intestines, and trachea. It details manufacturing techniques such as casting, electrospinning, 3D printing, and decellularization for creating functional tissue scaffolds.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Hollow organs and systems (vasculature, intestines, trachea) are crucial for bodily functions and disease research.
  • Tissue engineering aims to create functional tissue replacements for these vital structures.
  • Existing benchtop models serve as platforms for basic science and drug testing.

Purpose of the Study:

  • To review common tissue-engineered applications for tubular tissues.
  • To discuss manufacturing methods for producing tubular scaffolds.
  • To provide an overview of design criteria and state-of-the-art models in vascular, intestinal, and tracheal tissue engineering.

Main Methods:

  • Categorization of scaffold manufacturing techniques: casting, electrospinning, rolling, 3D printing, and decellularization.
Keywords:
3D printingbiomaterialsdecellularizationelectrospinningintestinelumentracheavascular

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Last Updated: Nov 24, 2025

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  • Discussion of general structure, anatomy, and design criteria for tubular tissue engineering.
  • Review of current models in vascular, intestinal, and tracheal tissue engineering.

    • Main Results:

    • Identified commonalities in producing tubular scaffolds, including intact openings and semi-permeable linings.
    • Presented a structured overview of diverse manufacturing methods for tubular tissue engineering.
    • Highlighted advanced tissue-engineered models for specific applications.

    Conclusions:

    • Manufacturing techniques for tubular scaffolds have converged due to common requirements.
    • The review provides a comprehensive resource on tubular tissue engineering methods and applications.
    • Future directions and advancements in the field are discussed.