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Updated: Nov 24, 2025
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant.
Amaresh Vanga1, Sandeep Magoon1, Jolanta Kowalewska2
1Department of Nephrology and Hypertension, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Case Reports in Nephrology and Dialysis
|December 28, 2020
Summary
This study highlights a rare kidney disease case that blurs the lines between fibrillary glomerulonephritis and immunotactoid glomerulonephropathy, suggesting an overlap variant. Further research is needed to understand these complex nephropathies.
Area of Science:
- Nephrology
- Pathology
- Electron Microscopy
Background:
- Fibrillary glomerulonephritis (FGN) and immunotactoid glomerulonephropathy (ITGN) are rare causes of nephrotic syndrome.
- Understanding the distinct pathological features and diagnostic markers, such as the DNA JB9 antigen in FGN, is crucial.
Observation:
- A middle-aged woman presented with nephrotic proteinuria, hematuria, and normal renal function.
- Renal biopsy showed randomly arranged, small, Congo red-negative fibrils with hollow cores.
Findings:
- The observed fibrils were negative for DNA JB9 antigen, differentiating it from typical FGN.
- The presence of hollow cores was consistent with ITGN, but the overall picture suggested an intermediate or overlap variant.
Implications:
- This case challenges strict classification of FGN and ITGN, indicating potential overlap or intermediate forms.
- Understanding these variants is critical for accurate diagnosis, treatment strategies, and prognosis in patients with glomerulonephritis.
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