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MXene Surface on Multiple Junction Triangles for Determining Osteosarcoma Cancer Biomarker by Dielectrode Microgap
Dakai Zhou1, Subash C B Gopinath2,3, Mohamed Shuaib Mohamed Saheed4,5
1Department of Spinal Surgery, Xinxiang Central Hospital, Xinxiang City, Henan Province 453000, People's Republic of China.
International Journal of Nanomedicine
|December 28, 2020
Summary
This study presents a novel MXene-based biosensor for detecting the survivin gene, a biomarker for osteosarcoma (OS). The developed dielectrode sensing platform achieves highly sensitive and specific detection of OS at low levels.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Nanomaterials offer sensitive and selective detection of clinical biomarkers for biosensor applications.
- MXene, a 2D layered transition metal, is attractive for biosensing due to its unique properties and biocompatibility.
Purpose of the Study:
- To develop a MXene-modified dielectrode sensing platform for diagnosing osteosarcoma (OS).
- To detect the survivin gene, a biomarker highly correlated with OS, at low concentrations.
Main Methods:
- Utilized MXene-modified multiple junction triangles on a dielectrode sensing platform.
- Immobilized capture DNA on MXene using 3-glycidoxypropyltrimethoxysilane as an amine linker.
- Detected target DNA sequences complementary to the survivin gene.
Main Results:
- Achieved a detection limit of 1 fM for the survivin gene with high specificity.
- Demonstrated excellent reproducibility across different batches of the sensing surface.
- Observed increased current with rising target DNA concentrations, confirming sensitivity.
Conclusions:
- The MXene-modified dielectrode device enables sensitive quantification of the survivin gene.
- This platform is beneficial for diagnosing osteosarcoma (OS) and assessing its complication levels.
