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The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease

Jia Liu1, Junduo Wu1, Longbo Li1

  • 1Department of Cardiology, The Second Hospital of Jilin University, Changchun, China.

Frontiers in Pharmacology
|December 28, 2020
PubMed

Insights

Exosomes carrying non-coding RNAs (ncRNAs) are crucial in cardiovascular disease (CVD) development. Understanding exosomal ncRNA mechanisms in atherosclerosis offers new diagnostic and therapeutic strategies for coronary artery disease (CAD).

Area of Science:

  • Biomedical Sciences
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disease (CVD), particularly atherosclerosis (AS), is a leading global cause of death.
  • Key factors in AS pathogenesis include oxidative stress, endothelial dysfunction, and inflammation.
  • Exosomes, nano-sized vesicles, mediate intercellular communication by transferring lipids, proteins, and RNA.

Purpose of the Study:

  • To review the role and regulatory mechanisms of exosomal non-coding RNAs (ncRNAs) in coronary artery disease (CAD) pathophysiology.
  • To explore the diagnostic and therapeutic potential of exosomal ncRNAs in CAD.

Main Methods:

  • Literature review focusing on exosomal ncRNAs in cardiovascular disease.
  • Analysis of molecular mechanisms underlying exosomal ncRNA function in atherosclerosis.
  • Synthesis of current research on exosomal ncRNA in CAD diagnosis and treatment.

Main Results:

  • Exosomal ncRNAs play a significant role in intercellular communication relevant to AS.
  • These ncRNAs can induce phenotypic changes and regulate cellular functions involved in CAD.
  • Exosomal ncRNAs are implicated in the complex pathophysiology of atherosclerosis.

Conclusions:

  • Elucidating exosomal ncRNA mechanisms provides insights into CAD development.
  • Exosomal ncRNAs represent promising biomarkers for CAD diagnosis.
  • Targeting exosomal ncRNAs offers potential therapeutic strategies for cardiovascular disease.

Keywords:
Non-coding RNAsacute myocardial infarctionatherosclerosiscoronary artery diseaseexosomes

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