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ATHEROGENIC INDICES IN THE ASSESSMENT OF CARDIOVASCULAR DISEASE RISK IN CHILDREN WITH OBESITY AND SUBCLINICAL
N Akici1, Z E Onal1, T Gürbüz1
1Istanbul Haydarpasa Numune Training and Research Hospital - Department of Pediatrics, Istanbul, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|December 28, 2020
Summary
Subclinical hypothyroidism (SH) in obese children is linked to higher risks of cardiovascular disease (CVD) due to unfavorable lipid profiles. This suggests SH may contribute to dyslipidemia and increase CVD risk in this population.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Risk Assessment
- Metabolic Disorders
Background:
- Subclinical hypothyroidism (SH) is more prevalent in obese children.
- Cardiovascular disease (CVD) risk in pediatric SH remains understudied.
- Lipid parameters are key indicators for early CVD detection.
Purpose of the Study:
- To evaluate lipid indices for predicting CVD risk in obese children with SH.
- To compare lipid indices with conventional lipid components in assessing CVD risk.
Main Methods:
- Study included 220 euthyroid obese children and 90 obese children with SH.
- Data collected retrospectively from hospital records.
- Calculated Atherogenic Index of Plasma (AIP), Cardiac Risk Ratio (CRR), and Atherogenic Coefficient (AC).
Main Results:
- Obese children with SH exhibited increased risk of higher AIP compared to euthyroid obese peers.
- The risk of elevated CRR was also significantly higher in obese children with SH.
Conclusions:
- Subclinical hypothyroidism in obese children is associated with dyslipidemia.
- This dyslipidemia profile may confer a heightened risk of cardiovascular disease.
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