Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Penicillin and the marked decrease in morbidity and mortality from rheumatic fever in the United States.

B F Massell1, C G Chute, A M Walker

  • 1Division of Medicine, Children's Hospital, Boston, Mass.

The New England Journal of Medicine
|February 4, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent ethanol exposure reprograms HMGB1 responsivity to adult ethanol challenge in males.

Physiology & behavior·2026
Same author

Computed tomography versus radiography for assessment of canine humeral condylar fracture malreductions.

New Zealand veterinary journal·2025
Same author

Development of a novel Bluetooth Low Energy device for proximity and location monitoring in grazing sheep.

Animal : an international journal of animal bioscience·2024
Same author

Neuroprotection by anaesthetics in rodent models of traumatic brain injury: a systematic review and network meta-analysis.

British journal of anaesthesia·2018
Same author

Point-of-care paediatric gastric sonography: can antral cut-off values be used to diagnose an empty stomach?

British journal of anaesthesia·2017
Same author

The kinematics and kinetics of riding a racehorse: A quantitative comparison of a training simulator and real horses.

Journal of biomechanics·2016
Same journal

Advances in Multiple Sclerosis.

The New England journal of medicine·2026
Same journal

Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis.

The New England journal of medicine·2026
Same journal

Adjuvant Pembrolizumab plus Belzutifan for Renal-Cell Carcinoma.

The New England journal of medicine·2026
Same journal

Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia.

The New England journal of medicine·2026
See all related articles

Penicillin significantly reduced rheumatic carditis severity and mortality starting in 1946. Continued diagnosis and treatment of streptococcal pharyngitis remain crucial for preventing rheumatic fever.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Rheumatic fever historically caused significant mortality.
  • Rheumatic carditis, a complication, led to severe heart damage.
  • The advent of antibiotics marked a potential turning point.

Purpose of the Study:

  • To evaluate the impact of penicillin on rheumatic carditis.
  • To analyze trends in rheumatic carditis mortality and murmur resolution.
  • To underscore the importance of treating streptococcal pharyngitis.

Main Methods:

  • Retrospective analysis of patient data from House of the Good Samaritan, Boston.
  • Examination of mortality rates for rheumatic carditis.
  • Assessment of murmur resolution rates in patients.

Related Experiment Videos

Main Results:

  • Penicillin use, beginning around 1946, correlated with a decline in rheumatic carditis severity.
  • Mortality due to rheumatic carditis decreased to zero at the studied hospital.
  • Murmur resolution rates accelerated post-1946, exceeding 40% by 1970.
  • National mortality rates for rheumatic carditis showed a fourfold acceleration in decline with antibiotic use.

Conclusions:

  • Penicillin played a critical role in reducing rheumatic carditis.
  • Antibiotics have dramatically decreased rheumatic fever's impact.
  • Prompt diagnosis and treatment of Group A streptococcal pharyngitis are essential for prevention.