Impaired syntactic comprehension and production in Broca's aphasia: CT lesion localization and recovery patterns

Three of 50 patients with left hemisphere stroke manifested Broca's aphasia associated with deficits in syntactic processing. CT demonstrated anterior infarcts in two patients and a posterior infarct in the third. Two years later, all three patients showed improved syntactic production, but only the patient with the posterior lesion performed significantly above change on a sentence comprehension test requiring syntactic manipulations in the absence of semantic constraints. Prospective investigations combining psycholinguistic analyses and brain imaging techniques may provide empiric data relevant to neurologic models of language and ultimately may contribute to patient prognostication and rehabilitation.