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Correlation Study of the Long-Term Prognosis of Venous Thromboembolism and Inflammatory Gene Polymorphisms

Refukaiti Abuduhalike1, Juan Sun1, Ailiman Mahemuti1

  • 1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, People's Republic of China.

International Journal of General Medicine
|December 28, 2020
PubMed

Insights

Inflammatory gene mutations, particularly IL-1 rs1800587, are linked to increased venous thromboembolism (VTE) mortality. Conversely, the IL-1 rs1143634 genotype may improve VTE patient survival, offering new prognostic insights.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Immunology

Background:

  • Venous thromboembolism (VTE) is a leading cause of cardiovascular death globally.
  • Many VTE risk factors remain unclear, necessitating research into novel prognostic markers.
  • Inflammatory pathways are implicated in VTE, but their specific role in prognosis requires further investigation.

Purpose of the Study:

  • To investigate the association between inflammatory gene polymorphisms and VTE prognosis.
  • To identify potential new predictors for VTE patient outcomes.
  • To explore the prognostic value of serum amyloid A protein (SAA), interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-α) gene variations.

Main Methods:

  • Plasma levels of SAA, IL-1, and TNF-α, along with 8 related gene polymorphisms, were analyzed in 284 VTE patients.
  • Detection methods included ELISA and multiplex ligation detection reaction (iMLDR).
  • Patients were followed for 5 years to assess all-cause mortality.

Main Results:

  • A high Simplified Pulmonary Embolism Severity Index (SPESI) score and the IL-1 rs1800587 mutant genotype were associated with significantly increased 5-year mortality in VTE patients.
  • The IL-1 rs1143634 mutant genotype was significantly associated with decreased mortality (HR=0.294).
  • No significant differences in mortality were observed for other tested genotypes (IL-1 rs1143634 wild-type, IL-1 rs2234650, SAA rs11603089, TNF-α rs1800629).

Conclusions:

  • A high SPESI score and the IL-1 rs1800587 genotype are predictors of shorter survival in VTE.
  • The IL-1 rs1143634 genotype is associated with improved survival in VTE patients.
  • Screening for inflammation-related gene mutations offers prognostic value for VTE clinical management.
Abstract

Keywords:
VTEgene polymorphisminflammatory markersprognosisvenous thromboembolism

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