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Related Experiment Videos

Adrenal masses in oncologic patients: functional and morphologic evaluation.

I R Francis1, A Smid, M D Gross

  • 1Department of Radiology, University of Michigan Medical Centers, Ann Arbor.

Radiology
|February 1, 1988
PubMed
Summary

Adrenocortical scintigraphy using NP-59 effectively differentiates adrenal masses in oncologic patients. Concordant uptake indicates adenomas, while discordant uptake suggests metastases or cysts, aiding diagnosis.

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Endocrinology

Background:

  • Unilateral adrenal masses are frequently detected via computed tomography (CT).
  • Differentiating benign from malignant adrenal lesions is crucial for patient management.
  • Adrenal function is typically normal in these cases.

Purpose of the Study:

  • To prospectively evaluate the role of adrenocortical scintigraphy with NP-59 in assessing unilateral adrenal masses.
  • To correlate scintigraphic findings with definitive diagnoses in oncologic patients.

Main Methods:

  • Prospective study of 28 oncologic patients with unilateral adrenal masses and normal adrenal function.
  • Adrenocortical scintigraphy performed using NP-59 (iodine-131-6-iodomethyl-19-norcholesterol).
  • Diagnosis confirmed by fine-needle aspiration cytology, surgical biopsy, or clinical/CT follow-up.

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Main Results:

  • Concordant NP-59 uptake (increased uptake on the side of the mass) was observed in 14 patients; 13 were adenomas (>2 cm).
  • Discordant NP-59 uptake (decreased uptake on the side of the mass) was seen in 11 patients; 9 were metastases, 2 were adrenal cysts.
  • Indeterminate uptake was noted in 3 patients with masses <2 cm; 2 adenomas, 1 metastasis.

Conclusions:

  • Adrenocortical scintigraphy with NP-59 is valuable in differentiating adrenal masses detected by CT in oncologic patients.
  • Concordant uptake strongly suggests adenoma, particularly for larger masses (>2 cm).
  • Discordant uptake is indicative of non-adenomatous lesions like metastases or cysts.