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Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
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Angiofluorographic Characteristics of Choroidal Neovascularization associated with Pathologic Myopia.
Anca Tomi1,2, Irina Ştefan3
1Emergency Eye Hospital, Bucharest, Romania.
Romanian Journal of Ophthalmology
|December 28, 2020
Summary
Choroidal neovascularization (CNV) is a common cause of visual loss in high myopia. Fluorescein angiography (FA) is crucial for detecting myopic CNV, though visual prognosis remains poor due to its location.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Pathologic myopia is a leading cause of visual impairment.
- Choroidal neovascularization (CNV) is a frequent complication of pathologic myopia.
- Recent visual loss in high myopic patients often indicates new-onset CNV.
Purpose of the Study:
- To determine the incidence of CNV in high myopic patients with recent visual loss.
- To characterize the features of myopic CNV using fluorescein angiography (FA).
Main Methods:
- Retrospective review of fluorescein angiograms from 89 high myopic patients.
- Analysis of 172 eyes, excluding those with specific ocular conditions.
- Evaluation of CNV incidence, angiofluorographic patterns, and location.
Main Results:
- CNV was detected in approximately 65% of analyzed eyes (66 out of 89 patients).
- Bilateral CNV was observed in 8 cases.
- The majority of CNVs were classic (56%), followed by cicatricial (24%) and occult (20%), predominantly in the subfoveal region.
Conclusions:
- New-onset myopic CNV is a primary cause of visual loss in high myopic individuals.
- Fluorescein angiography is essential for diagnosing myopic CNV and guiding treatment.
- Despite advancements, the visual prognosis for patients with sub/juxtafoveal CNV and extensive retinal lesions remains guarded.
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