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Acupoint Catgut Embedding Therapy for Abdominal Obesity Treatment
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An accurate and dual-effective body slimming method through a soluble microneedle patch with variable temperature.

Haichuan Peng1, Yan Zhou1, Chuxi Zhang1

  • 1The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, China. wangxiaolei@ncu.edu.cn.

Journal of Materials Chemistry. B
|December 28, 2020
PubMed
Summary

This study introduces a novel microneedle patch for obesity management, combining a weight-loss drug with melanin for enhanced fat reduction via near-infrared light and cold therapy. This offers a promising, non-surgical approach to body slimming.

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Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Pharmacology

Background:

  • Obesity is a complex, chronic disease with significant health risks.
  • Conventional weight-loss strategies often present limitations and side effects.
  • Novel, minimally invasive therapeutic approaches are needed for effective obesity management.

Purpose of the Study:

  • To develop and evaluate a microneedle (MN) patch system for targeted delivery of Rosiglitazone (Rosi) for weight loss.
  • To enhance drug release and therapeutic efficacy using a combination of photothermal and cryotherapy effects.
  • To provide an attractive, non-surgical alternative for precise body slimming management.

Main Methods:

  • Microneedle (MN) patches were formulated as drug carriers for Rosiglitazone.
  • Melanin was incorporated into the MN patches to augment photothermal effects under near-infrared (NIR) light.
  • The MN patches were applied, followed by NIR light exposure and external cold stimulation for targeted fat reduction.

Main Results:

  • The melanin-enhanced MN patches facilitated accelerated drug release to targeted adipose tissue under NIR irradiation.
  • The combined photothermal and cold stimulation approach demonstrated significant and accurate body slimming effects.
  • The soluble MN patch system proved effective in delivering the weight-loss drug to fat regions.

Conclusions:

  • The developed soluble microneedle patch system offers a novel, non-surgical method for obesity treatment.
  • Combining photothermal stimulation with cryotherapy enhances the efficacy of targeted drug delivery for body slimming.
  • This innovative approach presents a promising strategy for future accurate body slimming management.