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A non-linear regression method for estimation of gene-environment heritability.

Matthew Kerin1, Jonathan Marchini2

  • 1Wellcome Trust Center for Human Genetics, Oxford, OX3 7BN, UK.

Bioinformatics (Oxford, England)
|December 28, 2020
PubMed
Summary

We developed GPLEMMA, a novel method to estimate gene-environment interactions (GxE) heritability using environmental scores. This approach is computationally efficient for large datasets like the UK Biobank.

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