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Meningoencephalitis associated with COVID-19: a systematic review
Ritwick Mondal1, Upasana Ganguly1, Shramana Deb2
1Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research, SSKM Hospital, Kolkata, India.
Journal of Neurovirology
|December 28, 2020
Summary
This systematic review highlights the clinical, investigative, and radiological features of meningoencephalitis in COVID-19 patients. It summarizes findings from 61 cases, emphasizing the neurological manifestations of SARS-CoV-2 infection.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- The COVID-19 pandemic has seen an increase in patients presenting with extrapulmonary symptoms.
- Meningoencephalitis, a serious neurological complication, has been reported in association with SARS-CoV-2 infection.
Purpose of the Study:
- To systematically review and summarize the clinical profile, investigations, and radiological findings in patients with SARS-CoV-2-associated meningoencephalitis.
- To consolidate current evidence on the neurological impact of COVID-19.
Main Methods:
- A systematic review was conducted following PRISMA guidelines.
- Data was collected from PubMed/Medline, NIH LitCOVID, Embase, and Cochrane Library, including preprints up to June 30, 2020.
- Keywords included "SARS-COV-2," "COVID-19," and "meningoencephalitis." 61 cases from 25 studies were analyzed.
Main Results:
- Analysis included clinical, laboratory, neuroimaging, and electroencephalogram (EEG) findings.
- Fifty-four cases with complete investigation profiles were included in the final analysis.
- The review details the spectrum of meningoencephalitis presentations in COVID-19 patients.
Conclusions:
- This review synthesizes available evidence on meningoencephalitis occurring in the context of COVID-19.
- Understanding these neurological manifestations is crucial for patient management and further research.
- Further studies are needed to fully elucidate the pathophysiology and long-term outcomes.
