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Updated: Nov 24, 2025
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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
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Biomineralization of Trabecular Meshwork in Open-Angle Glaucoma
M V Kravchik1, A M Subbot2, I A Novikov2
1Research Institute of Eye Diseases, Moscow, Russia. kravchik.mv@gmail.com.
Doklady. Biochemistry and Biophysics
|December 28, 2020
Summary
A novel open-angle glaucoma subtype involves trabecular meshwork calcification and silicification, leading to outflow obstruction. Acid-base imbalances and melanosomal enzymes contribute to mineral formation in this glaucoma type.
Area of Science:
- Ophthalmology
- Pathology
- Biochemistry
Background:
- Open-angle glaucoma is a leading cause of irreversible blindness.
- Trabecular meshwork dysfunction is a key factor in intraocular pressure elevation.
- Mineralization in ocular tissues is increasingly recognized.
Purpose of the Study:
- To identify and characterize a new form of open-angle glaucoma.
- To investigate the role of calcification and silicification in trabecular meshwork outflow obstruction.
- To explore the contribution of acid-base balance and melanosomal enzymes to mineral deposition.
Main Methods:
- Histopathological analysis of trabecular meshwork.
- Biochemical assays to assess mineralization.
- Investigation of tissue acid-base status.
- Enzyme activity assays.
Main Results:
- Identification of a distinct subtype of open-angle glaucoma.
- Evidence of significant calcification and silicification in the trabecular meshwork.
- Correlation between acid-base disturbances and trabecular meshwork mineralization.
- Potential involvement of melanosomal enzymes in initiating calcium phosphate formation.
Conclusions:
- Trabecular meshwork mineralization is a significant factor in a newly identified form of open-angle glaucoma.
- Acid-base balance disturbances and melanosomal enzymes are implicated in the pathogenesis.
- This finding opens new avenues for understanding and potentially treating glaucoma.
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