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Hypercoagulopathy in Severe COVID-19: Implications for Acute Care
Alicia A C Waite1,2, David O Hamilton2, Roberto Pizzi3
1Institute for Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Thrombosis and Haemostasis
|December 28, 2020
Summary
COVID-19-associated coagulopathy (CAC) involves blood clotting issues, contributing to hypoxia. This review covers CAC diagnosis, treatment, and prevention strategies in acute care settings.
Area of Science:
- Emergency Medicine
- Critical Care
- Hematology
Background:
- COVID-19 pandemic has led to over 21 million global cases.
- COVID-19-associated coagulopathy (CAC) presents as hypercoagulability and immunothrombosis.
- CAC contributes to hypoxia and venous thromboembolism in affected patients.
Purpose of the Study:
- To review the diagnosis and treatment of CAC in emergency and intensive care settings.
- To summarize the pathological mechanisms and complications of CAC.
- To discuss current thromboprophylaxis and anticoagulation strategies for CAC.
Main Methods:
- Literature review of COVID-19-associated coagulopathy.
- Summary of pathological mechanisms and clinical manifestations.
- Analysis of diagnostic and therapeutic approaches in acute care.
Main Results:
- CAC is characterized by hypercoagulability, immunothrombosis, and venous thromboembolism.
- Complications include pulmonary thrombosis and venous thromboembolic events.
- Effective diagnosis and management are crucial for patient outcomes.
Conclusions:
- Timely diagnosis and appropriate management of CAC are essential in acute care.
- Understanding pathological mechanisms informs treatment strategies.
- Current strategies focus on thromboprophylaxis and therapeutic anticoagulation.
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