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Hypercoagulopathy in Severe COVID-19: Implications for Acute Care

Alicia A C Waite1,2, David O Hamilton2, Roberto Pizzi3

  • 1Institute for Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

Thrombosis and Haemostasis
|December 28, 2020
PubMed

Insights

COVID-19-associated coagulopathy (CAC) involves blood clotting issues, contributing to hypoxia. This review covers CAC diagnosis, treatment, and prevention strategies in acute care settings.

Area of Science:

  • Emergency Medicine
  • Critical Care
  • Hematology

Background:

  • COVID-19 pandemic has led to over 21 million global cases.
  • COVID-19-associated coagulopathy (CAC) presents as hypercoagulability and immunothrombosis.
  • CAC contributes to hypoxia and venous thromboembolism in affected patients.

Purpose of the Study:

  • To review the diagnosis and treatment of CAC in emergency and intensive care settings.
  • To summarize the pathological mechanisms and complications of CAC.
  • To discuss current thromboprophylaxis and anticoagulation strategies for CAC.

Main Methods:

  • Literature review of COVID-19-associated coagulopathy.
  • Summary of pathological mechanisms and clinical manifestations.
  • Analysis of diagnostic and therapeutic approaches in acute care.

Main Results:

  • CAC is characterized by hypercoagulability, immunothrombosis, and venous thromboembolism.
  • Complications include pulmonary thrombosis and venous thromboembolic events.
  • Effective diagnosis and management are crucial for patient outcomes.

Conclusions:

  • Timely diagnosis and appropriate management of CAC are essential in acute care.
  • Understanding pathological mechanisms informs treatment strategies.
  • Current strategies focus on thromboprophylaxis and therapeutic anticoagulation.

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