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Updated: Nov 24, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
Infections and AA amyloidosis: An overview
Samuel Deshayes1, Achille Aouba1, Gilles Grateau2
1Service de médecine interne, Normandie University, UNICAEN, CHU de Caen Normandie, Caen, France.
AA amyloidosis, a disease linked to protein buildup, is increasingly caused by inflammatory conditions rather than infections. Despite medical advances, infections still cause 5-30% of cases, highlighting the need for better infection screening and management.
Area of Science:
- Medicine
- Pathology
- Immunology
Background:
- Amyloidoses involve extracellular accumulation of misfolded proteins into amyloid fibrils.
- Inflammatory (AA) amyloidosis results from serum amyloid A (SAA) protein overproduction during sustained inflammation.
- Chronic infections were historically primary causes of AA amyloidosis, but their frequency has declined.
Purpose of the Study:
- To review infections associated with AA amyloidosis.
- To determine the relative frequency of infections as etiological factors in AA amyloidosis.
Main Methods:
- Literature search of the PubMed database.
- Used MeSH terms "Amyloidosis" and "Infections" from inception to December 31st, 2019.
- Included only English and French articles.
Main Results:
- AA amyloidosis secondary to infections decreased from over 50% to under 20% post-2000.
- A concurrent rise in AA amyloidosis from inflammatory diseases and unknown causes was observed.
- Infections remain a cause in 5-30% of AA amyloidosis cases, even in developed nations.
Conclusions:
- Despite improved sanitation and antibiotics, infections persist as a significant cause of AA amyloidosis.
- Enhanced screening for chronic infections is crucial for AA amyloidosis prevention.
- New management strategies for recurrent infections are needed to combat AA amyloidosis.
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