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Menstrual disorders associated with sirolimus treatment
Paloma Triana1, Juan Carlos López-Gutierrez1
1Vascular Anomalies Unit, Department of Pediatric Surgery, Children's Hospital La Paz, Madrid, Spain.
Pediatric Blood & Cancer
|December 28, 2020
Summary
Sirolimus treatment for vascular anomalies can cause menstrual disorders in women. These side effects are usually mild and reversible, but awareness is crucial for patients and physicians.
Area of Science:
- Vascular Medicine
- Pharmacology
- Gynecology
Background:
- Sirolimus, an mTOR inhibitor, is a key treatment for vascular anomalies.
- Adverse effects of sirolimus are known, but menstrual disorders are not well-documented.
Purpose of the Study:
- To investigate the occurrence and characteristics of menstrual disorders in patients with vascular anomalies treated with sirolimus.
Main Methods:
- Retrospective review of 136 patients with vascular anomalies on sirolimus.
- Inclusion criteria: patients presenting with menstrual alterations during treatment.
Main Results:
- Seven out of 74 female patients (9.4%) experienced menstrual alterations attributed to sirolimus.
- Most experienced mild hypermenorrhea or metrorrhagia, often reversible.
- One patient discontinued treatment due to severe symptoms, with cycles normalizing post-cessation.
Conclusions:
- Sirolimus treatment can lead to menstrual disorders as a side effect.
- These menstrual changes are typically mild and reversible upon dose adjustment or discontinuation.
- Patients and healthcare providers should be aware of this potential adverse effect.
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