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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
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Syntheses and Transformations of Sulfoximines
Wenting Zheng1, Xianlie Chen1, Feng Chen1
1State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, College of Materials, Chemistry & Chemical Engineering, Chengdu University of Technology, 1 Dongsan Road, Erxianqiao, Chengdu, 610059, China.
Chemical Record (New York, N.Y.)
|December 28, 2020
Summary
This review covers synthetic methods and transformations for NH-sulfoximines, crucial compounds in pharmaceuticals, agrochemicals, and asymmetric synthesis. It highlights their versatility and importance in creating complex molecules.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Asymmetric Synthesis
Background:
- Sulfoximines are versatile compounds with broad applications in medicine, agriculture, and catalysis.
- NH-sulfoximines serve as key intermediates for synthesizing heterocyclic compounds and chiral ligands.
- Their synthesis and functionalization are critical for developing new chemical entities.
Purpose of the Study:
- To provide a comprehensive review of synthetic methodologies for NH-sulfoximines.
- To summarize the diverse transformations and reactions involving NH-sulfoximines.
- To highlight the significance of NH-sulfoximines in various chemical fields.
Main Methods:
- Review of literature on NH-sulfoximine synthesis from precursors like thioethers, sulfoxides, sulfilimines, and sulfinamides.
- Analysis of various chemical transformations including arylations, alkylations, vinylations, and alkynylations.
- Compilation of established and emerging synthetic routes and reaction pathways.
Main Results:
- Detailed overview of established methods for NH-sulfoximine preparation.
- Catalog of key reactions enabling the functionalization of NH-sulfoximines.
- Demonstration of NH-sulfoximines' utility as building blocks in organic synthesis.
Conclusions:
- NH-sulfoximines are indispensable in modern chemistry due to their wide-ranging applications.
- The reviewed synthetic methods and transformations offer valuable tools for chemists.
- Further exploration of NH-sulfoximine chemistry promises advancements in drug discovery and materials science.
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