Related Experiment Video

Updated: Nov 24, 2025

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

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Frontiers in HER2-positive breast cancer in 2020

Parvin F Peddi1, Dennis J Slamon

  • 1University of California, Los Angeles, USA.

Current Opinion in Obstetrics & Gynecology
|December 28, 2020
PubMed
Abstract

Insights

Recent advances in HER2-positive breast cancer treatment include four new FDA-approved drugs. These therapies are becoming standard of care and may extend to HER2-low breast cancer patients.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • HER2-positive breast cancer treatment has rapidly evolved.
  • Significant advancements in therapeutic options have emerged in the last two years.

Purpose of the Study:

  • To summarize cutting-edge research and future directions in HER2-positive breast cancer.
  • To review recent drug approvals and clinical trial data.

Main Methods:

  • Review of clinical data for four new drugs in HER2-positive breast cancer treatment.
  • Analysis of ongoing clinical trials, including immunotherapy and CDK4/6 inhibitors.
  • Examination of therapeutic roles in advanced and HER2-low breast cancer.

Main Results:

  • Three new drugs have received FDA approval within the past 18 months.
  • These novel therapies are rapidly establishing themselves as standard of care.
  • Potential for expanded application to HER2-low breast cancer is indicated.

Conclusions:

  • Recent therapeutic advancements represent a significant shift in HER2-positive breast cancer management.
  • These new treatments offer improved options for patients with advanced disease.
  • The scope of these therapies may broaden to include HER2-low breast cancer.

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