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Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

241
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
241

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Updated: Nov 24, 2025

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
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Gastrointestinal Bleeding Rates in Left Ventricular Assist Device Population Reduced with Octreotide Utilization.

Tyler J Wilson1, David A Baran2, John M Herre2

  • 1From the Pharmacy Department, Sentara Norfolk General Hospital, Norfolk, Virginia.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 28, 2020
PubMed
Summary
This summary is machine-generated.

Octreotide significantly reduced gastrointestinal bleeding (GIB) in patients with left ventricular assist devices. This treatment offers a new option for preventing recurrent GIB in high-risk individuals.

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Medical Devices

Background:

  • Patients with continuous-flow left ventricular assist devices (LVADs) face a high risk of gastrointestinal bleeding (GIB).
  • Recurrent GIB poses a significant challenge in this patient population, often requiring intensive management.
  • Existing therapies may not be sufficient for all patients at risk.

Purpose of the Study:

  • To evaluate the efficacy of octreotide in preventing recurrent GIB among patients with LVADs.
  • To assess the impact of octreotide on the frequency of GIB events in this cohort.

Main Methods:

  • A retrospective, case-crossover study design was employed.
  • 32 patients with LVADs who received octreotide for GIB prevention were analyzed.
  • GIB hospital admissions were compared before and after octreotide initiation, with each patient serving as their own control.

Main Results:

  • Octreotide significantly decreased the overall frequency of GIB from 4.3 to 0.9 events per year (p < 0.001).
  • 59.4% of patients experienced no subsequent GIB after starting octreotide.
  • For patients who did rebleed, octreotide reduced the event frequency by 2.6 bleeds per patient per year (p = 0.043).

Conclusions:

  • Octreotide is effective in reducing the frequency of recurrent gastrointestinal bleeding in patients with left ventricular assist devices.
  • This finding suggests octreotide is a valuable therapeutic option for high-risk LVAD patients who have not responded to conventional treatments.
  • Further research may explore optimal dosing and long-term outcomes of octreotide in this specific patient group.