Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of an Ophthalmic Cooling Device on Corneal Immune and Sensory Nerve Features in Chronic Ocular Surface Pain: A Prospective, Feasibility Study.

Ophthalmology and therapy·2026
Same author

LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations.

Molecular cancer therapeutics·2026
Same author

Anterior cerebral artery variants and their influence on endovascular outcomes: a propensity score matched analysis from the CRETA registry.

Neuroradiology·2026
Same author

Editorial: Bioengineering and biotechnology approaches in cardiovascular sciences, volume III.

Frontiers in bioengineering and biotechnology·2026
Same author

Magnetic Resonance Imaging/Diffusion-Weighted Imaging-Guided Versus Perfusion-Guided Intravenous Thrombolysis with Alteplase Beyond 4.5-Hour Window: a Network Meta-Analysis of Randomized Controlled Trials.

Clinical neuroradiology·2026
Same author

Out-of-pocket costs for people with tuberculosis disease in Toronto, Canada: A web-based survey at two tuberculosis treatment centres, April 2023-April 2025.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2026

Related Experiment Video

Updated: Nov 24, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

601

Transient Reticular Cystic Corneal Epithelial Edema With Topical Netarsudil: A Case Series and Review.

Stephen A LoBue1, Giannis A Moustafa1, Anderson Vu2

  • 1Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.

Cornea
|December 28, 2020
PubMed
Summary

Netarsudil ophthalmic solution can cause reversible, reticular cystic epithelial edema in patients with corneal edema. This side effect resolved after discontinuing the rho-kinase inhibitor eye drops.

More Related Videos

Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
04:00

Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings

Published on: August 2, 2024

2.8K
Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
07:39

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

2.4K

Related Experiment Videos

Last Updated: Nov 24, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

601
Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
04:00

Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings

Published on: August 2, 2024

2.8K
Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
07:39

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

2.4K

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Pharmacology

Background:

  • Rho-kinase inhibitors are used to treat various eye conditions.
  • Netarsudil ophthalmic solution is a rho-kinase inhibitor.
  • Potential side effects of ophthalmic solutions require thorough investigation.

Purpose of the Study:

  • To describe cases of netarsudil ophthalmic solution 0.02% causing reversible, reticular cystic epithelial edema.
  • To analyze the clinical presentation and resolution of this specific adverse event.

Main Methods:

  • Retrospective case review of patients treated with netarsudil.
  • Analysis of patients who developed corneal stromal and subsequent cystic epithelial edema.
  • Clinical data including visual acuity and corneal thickness were assessed.

Main Results:

  • Four male patients (mean age 72) developed reticular, honeycomb-like epithelial edema.
  • Edema appeared within 1-2 months of starting netarsudil.
  • Epithelial cysts resolved within 2 weeks of discontinuing netarsudil.
  • Corneal thickness and visual acuity changes varied among patients.

Conclusions:

  • Netarsudil can induce transient, reversible cystic epithelial edema in a subset of patients with pre-existing corneal edema.
  • The incidence may be higher than previously recognized.
  • Further large-scale studies are needed to determine the clinical significance.