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Related Experiment Videos

Marrow fibrosis and multiple myeloma.

R L Krzyzaniak1, D H Buss, M R Cooper

  • 1Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.

American Journal of Clinical Pathology
|January 1, 1988
PubMed
Summary

Simple marrow fibrosis (SMF) was found in 8.8% of multiple myeloma (MM) patients. This condition can hinder bone marrow aspirates, potentially necessitating bone marrow biopsies for accurate MM diagnosis.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Multiple myeloma (MM) is a hematologic malignancy.
  • Bone marrow fibrosis can complicate MM diagnosis and treatment.
  • The association between MM and simple marrow fibrosis (SMF) is not well-documented in existing literature.

Purpose of the Study:

  • To determine the frequency of SMF in patients with MM.
  • To assess the clinical significance of SMF in the context of MM diagnosis.

Main Methods:

  • Retrospective review of pretreatment bone marrow samples from 297 MM patients.
  • Analysis of hematoxylin and eosin-stained sections.
  • Confirmation of fibrosis using reticulin and trichrome stains.

Main Results:

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  • Simple marrow fibrosis (SMF) was confirmed in 26 out of 297 (8.8%) MM patients.
  • Seven of these cases also exhibited collagen deposition.
  • SMF was noted to cause inadequate bone marrow aspirates, leading to inconclusive results.

Conclusions:

  • Simple marrow fibrosis (SMF) is present in a notable proportion of multiple myeloma (MM) cases.
  • The presence of SMF can compromise the diagnostic yield of bone marrow aspirates.
  • Bone marrow trephine biopsies may be essential for accurate MM diagnosis when SMF is suspected.