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Updated: Nov 24, 2025

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Drug dosing in cancer patients with decreased kidney function: A practical approach
Ben Sprangers1, Geeta Sandhu2, Mitchel H Rosner3
1Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven and Division of Nephrology, University Hospitals Leuven, Both in Leuven, Belgium.
Abstract:
Correct drug dosing of anticancer agents is essential to obtain optimal outcomes. Overdosing will result in increased toxicity, treatment interruption and possible cessation of anticancer treatment. Underdosing may result in suboptimal anti-cancer effects and may increase the risk of cancer-related mortality. As it is practical nor feasible to perform therapeutic drug monitoring for all anti-cancer drugs, kidney function is used to guide drug dosing for those drugs whose primary mode of excretion is through the kidney. However, it is not well-established what method should be utilized to measure or estimate kidney function and the choice of method does influence treatment decisions regarding eligibility for anti-cancer drugs and their dose. In this review, we will provide an overview regarding the importance of drug dosing, the preferred method to determine kidney function and a practical approach to drug dosing of anticancer drugs.
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