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Updated: Nov 24, 2025
Dissection and Lateral Mounting of Zebrafish Embryos: Analysis of Spinal Cord Development
Published on: February 28, 2014
Role of serotonin in vertebrate embryo development
Jessica Romero-Reyes1, Anayansi Molina-Hernández2, Néstor Fabián Díaz2
1Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México. Mexico City, Mexico.
Abstract:
Since its discovery in 1937, serotonin (5-HT) has become one of the most studied biogenic amines due to its predominant role in regulating several physiological processes such as mood, sleep, and food intake. This amine and the main components of the serotoninergic system are in almost all cells of the body. The presence of 5-HT and the serotoninergic system has been observed in oocytes and in different embryo development stages of fish, amphibians, birds, and mammals. In several classes of vertebrates, the change in the concentration of 5-HT or the alteration of the serotoninergic system, interfere with early embryo development. These data suggest that 5-HT participates in embryo development of vertebrates.
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