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Prosopagnosia seizure semiology in a 10-year-old boy: a functional neuroimaging study

Jack Lam1, Jeremy T Moreau1, Jen-Kai Chen2,3

  • 1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.

BMJ Case Reports
|December 29, 2020
PubMed

Insights

This study presents a pediatric case of temporary face blindness (prosopagnosia) after head trauma. Advanced imaging confirmed a brain lesion near the face recognition area, explaining the recurrent episodes.

Area of Science:

  • Neuroscience
  • Neurology
  • Pediatric Neurology

Background:

  • Post-traumatic prosopagnosia is rare in children.
  • Recurrent transient prosopagnosia can be associated with focal brain lesions and seizures.

Observation:

  • A pediatric patient experienced recurrent episodes of transient prosopagnosia following a head injury.
  • Imaging revealed a hemorrhage in the right posterior inferior temporal gyrus.
  • Interictal electroencephalogram showed abnormalities in the right posterior quadrant.

Findings:

  • Magnetoencephalography (MEG) and functional MRI (fMRI) mapped face recognition areas.
  • These techniques showed activation in the right fusiform gyrus, colocalizing with the lesion.
  • This suggests the lesion's proximity to the fusiform face area caused the prosopagnosia.

Implications:

  • Lesions near the right fusiform gyrus can trigger seizures manifesting as transient prosopagnosia.
  • MEG and fMRI are valuable tools for attributing unique symptoms to specific brain lesions.
  • This case highlights the intricate relationship between brain structure, function, and complex cognitive deficits.

Keywords:
epilepsy and seizuresneuroimagingneurosurgerypaediatric surgery

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