Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An epidemiologic approach to ecogenetics.

M J Khoury1, M J Adams, W D Flanders

  • 1Division of Birth Defects and Developmental Disabilities, Centers for Disease Control, Atlanta, GA 30333.

American Journal of Human Genetics
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insights from a methylome-wide association study of antidepressant exposure.

Nature communications·2025
Same author

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

Molecular psychiatry·2024
Same author

Chytrid infections exhibit historical spread and contemporary seasonality in a declining stream-breeding frog.

Royal Society open science·2024
Same author

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

medRxiv : the preprint server for health sciences·2024
Same author

White matter, cognition and psychotic-like experiences in UK Biobank.

Psychological medicine·2023
Same author

IgG fractions from patients with antiphospholipid syndrome and systemic lupus erythematosus bind to platelets, but do not affect collagen-induced platelet activation.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2022
Same journal

Bi-allelic missense variants in human GPN2 result in Perrault syndrome.

American journal of human genetics·2026
Same journal

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

American journal of human genetics·2026
Same journal

A transparent and generalizable deep-learning framework for genomic ancestry prediction.

American journal of human genetics·2026
Same journal

Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome.

American journal of human genetics·2026
Same journal

Linkage disequilibrium and allelic heterogeneity explain variation in coronary artery disease risk at 9p21 across populations and reduced effect in Africans.

American journal of human genetics·2026
Same journal

Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.

American journal of human genetics·2026
See all related articles

Ecogenetics research must consider environmental factors. Genetic marker-disease links depend on exposure frequency and interaction strength, not just genetics alone.

Area of Science:

  • Epidemiology
  • Genetics
  • Environmental Health

Background:

  • Ecogenetics aims to link genetic differences to environmental susceptibility.
  • Current research often overlooks environmental determinants when studying genetic markers and disease.
  • Epidemiologic definitions of genotype-environment interaction provide a framework for analysis.

Purpose of the Study:

  • To demonstrate how relative risk for genetic markers is influenced by environmental factors.
  • To illustrate patterns of genotype-environment interaction and their impact on disease risk.
  • To advocate for the inclusion of environmental determinants in genetic association studies.

Main Methods:

  • Utilizing epidemiologic definitions of genotype-environment interaction.

Related Experiment Videos

  • Analyzing the relationship between genetic markers, environmental agent exposure, and disease risk.
  • Illustrating findings with examples from existing literature.

    • Main Results:

    • Relative risk associated with a genetic marker fluctuates based on environmental exposure frequency and interaction strength.
    • Infrequent environmental exposures can mask strong genotype-environment interactions, yielding near-unity relative risk.
    • Elevated relative risks indicate either frequent environmental exposure or strong interaction patterns.

    Conclusions:

    • Genetic marker-disease associations require evaluation within a comprehensive epidemiologic study design.
    • Specific environmental determinants must be considered to accurately assess genetic risk.
    • Understanding genotype-environment interactions is crucial for advancing ecogenetics research.