Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

9.3K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
9.3K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

5.5K
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
5.5K
Anaphase A and B01:39

Anaphase A and B

4.9K
Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
4.9K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

4.4K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.4K
Energy to Drive Translocation01:37

Energy to Drive Translocation

2.5K
Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
2.5K
ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

16.0K
In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
16.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Ameliorating effect of Citri Reticulatae Pericarpium on hypercholesterolemia in rats through promoting reverse cholesterol transport].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

Utilizing Light to Control Glycopolymer-DC-SIGN Interactions via Molecular Motors.

Journal of the American Chemical Society·2026
Same author

Dynamic Self-Healing Polymer Architectures for High-Performance Flexible Sensing.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Trefoil polymers from a knotted synthon.

Nature chemistry·2026
Same author

Light-Driven Dual Rotary Molecular Motors and Beyond.

Accounts of chemical research·2026
Same author

Benzene at 200: from a simple ring to a universe of fused aromatic carbon.

Chemical science·2026

Related Experiment Video

Updated: Nov 24, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

11.7K

Visible-Light-Driven Rotation of Molecular Motors in Discrete Supramolecular Metallacycles.

Zhao-Tao Shi1, Yi-Xiong Hu2, Zhubin Hu3

  • 1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

Journal of the American Chemical Society
|December 29, 2020
PubMed
Summary

Researchers created visible-light-responsive metallacycles using molecular motors. These structures enable controlled collective motion and hierarchical self-assembly for advanced adaptive materials.

More Related Videos

Construction and Operation of a Light-driven Gold Nanorod Rotary Motor System
09:48

Construction and Operation of a Light-driven Gold Nanorod Rotary Motor System

Published on: June 30, 2018

9.1K
Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
08:04

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

7.1K

Related Experiment Videos

Last Updated: Nov 24, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

11.7K
Construction and Operation of a Light-driven Gold Nanorod Rotary Motor System
09:48

Construction and Operation of a Light-driven Gold Nanorod Rotary Motor System

Published on: June 30, 2018

9.1K
Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
08:04

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

7.1K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Organizing molecular motors into supramolecular assemblies is key for responsive systems.
  • Metal-coordination-driven self-assembly into metallacycles offers precise control over motor positioning.
  • Developing systems for amplified and transmitted motion is crucial for future technologies.

Purpose of the Study:

  • To design and synthesize visible-light-responsive metallacycles incorporating molecular motors.
  • To investigate the cooperative motion and hierarchical self-assembly capabilities of these metallacycles.
  • To explore the potential of these systems in creating dynamic, adaptive materials.

Main Methods:

  • Synthesis of a pyridyl-modified molecular motor ligand (MPY) and its coordination with di-Pt(II) acceptors.
  • Characterization of metallacycle formation, size, and shape using various spectroscopic and microscopic techniques.
  • Photochemical and thermal isomerization studies, Circular Dichroism (CD) spectroscopy, and dynamic light scattering (DLS) to assess motor function and aggregation behavior.

Main Results:

  • Discrete metallacycles of varying sizes and shapes were successfully assembled, exhibiting red-shifted absorption bands responsive to visible light.
  • Light-driven rotation of molecular motors within the metallacycles was confirmed, preserving helicity inversions during isomerization.
  • Hierarchical self-assembly of a trimeric metallacycle with heparin demonstrated selective manipulation of secondary aggregation without disrupting primary structures.

Conclusions:

  • Visible-light-responsive metallacycles containing multiple rotary motors can be controllably assembled.
  • These systems facilitate cooperative motion and the creation of dynamic hierarchical structures.
  • The developed metallacycles show promise for applications in adaptive materials and responsive systems.