ACE2 as a Potential Target for Management of Novel Coronavirus (nCoV- 2019)

Area of Science:

• Virology
• Pathobiology
• Cardiovascular Physiology

Background:

• A novel coronavirus (nCoV-2019) emerged in Wuhan, China, in December 2019, causing a global epidemic of acute respiratory syndrome.
• The disease has resulted in numerous fatalities worldwide, with no specific treatments currently available.
• The renin-angiotensin system (RAS) plays crucial physiological roles and is implicated in various disease pathologies.

Purpose of the Study:

• To explore the potential role of the angiotensin-converting enzyme 2 (ACE2) receptor in the pathogenesis of nCoV-2019-induced acute respiratory syndrome.
• To provide insights into ACE2 as a therapeutic target for nCoV-2019 infection.

Main Methods:

• This is a review article.
• It synthesizes current understanding of the renin-angiotensin system and its interaction with nCoV-2019.
• Focuses on the ACE2 receptor's function and implications in viral entry and disease progression.

Main Results:

• The nCoV-2019 virus utilizes the ACE2 receptor for cellular entry, highlighting its critical role in infection.
• Dysregulation of the renin-angiotensin system, particularly involving ACE2, may contribute to the severity of acute respiratory syndrome.
• ACE2's involvement suggests potential therapeutic strategies targeting this pathway.

Conclusions:

• The angiotensin-converting enzyme 2 (ACE2) receptor is a key factor in the pathogenesis of nCoV-2019.
• Targeting the ACE2 receptor presents a promising avenue for developing treatments against nCoV-2019-induced acute respiratory syndrome.
• Further research into the ACE2 pathway is crucial for combating the ongoing epidemic.