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A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2

Mohana Das1, Manish Kumar1, Abhishek Jha1

  • 1Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh-221005, India.

Current Drug Targets
|December 29, 2020
PubMed

Insights

The COVID-19 pandemic necessitates rapid drug discovery. This review explores in-silico, in-vitro, and in-vivo screening models to identify effective treatments and vaccines for SARS-CoV-2.

Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Coronaviruses, including MERS-CoV and SARS-CoV, are RNA viruses impacting multiple systems.
  • The novel SARS-CoV-2 virus causes the widespread COVID-19 pandemic.
  • Current treatments for COVID-19 are limited, creating an urgent need for new therapeutic strategies.

Purpose of the Study:

  • To review and discuss various screening models for identifying potential COVID-19 therapeutics.
  • To highlight methods for discovering new drug candidates, vaccines, and drug targets.
  • To summarize the current status of drugs and vaccines in clinical trials for COVID-19.

Main Methods:

  • In-silico screening approaches for computational drug discovery.
  • In-vitro assays for evaluating compound efficacy against SARS-CoV-2.
  • In-vivo models for preclinical assessment of therapeutic candidates.

Main Results:

  • Discussion of diverse screening methodologies applicable to COVID-19 drug development.
  • Identification of potential therapeutic targets and drug repurposing opportunities.
  • Overview of ongoing clinical investigations for COVID-19 treatments and vaccines.

Conclusions:

  • Effective screening models are crucial for accelerating the development of COVID-19 therapies.
  • A multi-pronged approach combining in-silico, in-vitro, and in-vivo methods is essential.
  • Continued research and clinical trials are vital for managing the COVID-19 pandemic.
Keywords:
COVID-19Corona VirusMiddle East Coronavirus Respiratory Syndrome (MERS-CoV)SARS-CoVScreening Modelsenteric

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