Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capillary structure in elastase-induced emphysema.

D E Schraufnagel1, A Schmid

  • 1Department of Medicine, University of Illinois, Chicago 60680.

The American Journal of Pathology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved Quantification of Circulating Tumor DNA in Translocation-Associated Myxoid Liposarcoma by Simultaneous Detection of Breakpoints and Single Nucleotide Variants.

Cancer medicine·2025
Same author

[Complete regression of a choroidal metastasis from melanoma with dual targeted therapy].

Journal francais d'ophtalmologie·2023
Same author

Non-surgical external jugular vein catheterization using an ear vein access in piglets.

Laboratory animals·2023
Same author

Noise-optimized virtual monoenergetic reconstructions of dual-energy CT angiographies improve assessability of the lower leg arterial segments in peripheral arterial occlusive disease.

Radiography (London, England : 1995)·2022
Same author

T2-weighted MRI defines critical compression in the distal carpal tunnel that is relieved after decompressive surgery.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2022
Same author

Targeted next-generation sequencing of circulating free DNA enables non-invasive tumor detection in myxoid liposarcomas.

Molecular cancer·2022

In experimental emphysema, researchers observed capillary changes like abrupt endings and increased folds, indicating structural damage. Decreased elastic recoil appears to precede widespread capillary loss in this lung disease model.

Area of Science:

  • Pulmonary Medicine
  • Vascular Biology
  • Pathology

Background:

  • Pulmonary emphysema involves alveolar destruction.
  • Capillary damage and microvascular remodeling in emphysema are poorly understood.
  • Alveolar walls are largely composed of capillaries.

Purpose of the Study:

  • To investigate capillary structural changes in experimental emphysema.
  • To determine if capillary loss parallels alveolar destruction.
  • To identify microvascular remodeling in emphysema.

Main Methods:

  • Scanning electron microscopy of vascular casts from rat lungs.
  • Intratracheal instillation of elastase to induce emphysema.
  • Analysis of lung pressure-volume curves and light microscopy.

Related Experiment Videos

Main Results:

  • Elastase-treated rats showed alveolar enlargement consistent with emphysema.
  • Capillary casts exhibited abrupt endings near destroyed lung areas.
  • Increased nonconnecting capillary segments and folds were observed, suggesting weakened alveolar walls.
  • Capillary density decreased on the pleural surface, potentially due to hyperinflation.
  • No significant changes in capillary diameter or branching frequency were found.

Conclusions:

  • Experimental emphysema involves distinct capillary structural alterations, not just diffuse loss.
  • Decreased elastic recoil may occur before significant capillary loss in emphysema.
  • Microvascular remodeling, including capillary damage, is a feature of this emphysema model.