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[Human granulocytic anaplasmosis: an autochthonous tick-borne disease with a potentially severe course].

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Perinatal transmission of <i>Borrelia burgdorferi:</i> advancing scientific and clinical understanding of Lyme disease in pregnancy.

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Pathogenesis of Relapsing Fever.

Job Lopez1, Joppe W Hovius2, Sven Bergström3

  • 1Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston TX, USA.

Current Issues in Molecular Biology
|December 29, 2020
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Summary
This summary is machine-generated.

Relapsing fever (RF) is caused by Borrelia bacteria, transmitted by ticks or lice. This review covers RF Borrelia transmission, taxonomy, pathogenesis, and immune evasion strategies.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Relapsing fever (RF) is a group of diseases caused by Borrelia species.
  • Transmission occurs via soft ticks, body lice (Borrelia recurrentis), or hard ticks (Borrelia miyamotoi).
  • RF Borrelia possess pathogenic features enabling host invasion and dissemination.

Purpose of the Study:

  • To discuss the dynamics of vector acquisition and transmission of RF Borrelia.
  • To review taxonomic challenges and emerging species of RF Borrelia.
  • To explore pathogenesis, including symptomology, neurotropism, adhesion, and immune evasion.

Main Methods:

  • Review of existing literature on RF Borrelia.
  • Analysis of transmission dynamics and vector-host interactions.
  • Discussion of pathogenic mechanisms and immune evasion strategies.

Main Results:

  • RF Borrelia exhibit diverse transmission routes and vectors.
  • Taxonomic classification faces challenges due to newly isolated species globally.
  • Pathogenesis involves multiphasic antigenic variation for immune evasion.

Conclusions:

  • Understanding RF Borrelia transmission and pathogenesis is crucial for disease control.
  • Ongoing research into new species and evasion strategies is vital.
  • Future directions focus on managing this global infectious disease.