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Updated: Nov 24, 2025
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Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
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Senescence research from historical theory to future clinical application
Masahiro Kameda1, Takumi Mikawa2, Masayuki Yokode1
1Geriatric unit, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Geriatrics & Gerontology International
|December 29, 2020
Summary
Cellular senescence, a key factor in aging, involves processes like replicative and stress-induced senescence. Biomarkers such as telomere length, p16, p53, and inflammatory cytokines are crucial for understanding aging and related diseases.
Area of Science:
- Gerontology
- Cell Biology
- Molecular Biology
Background:
- Cellular lifespan studies significantly impact aging research.
- Replicative senescence (Hayflick) led to telomere and telomerase research.
- Stress-induced senescence is a telomere-independent process involving tumor suppressors like p53 and p16 Ink4a.
Purpose of the Study:
- To review the role of cellular senescence in aging.
- To highlight biomarkers of cellular senescence.
- To discuss the clinical implications of senescence research, including senolysis.
Main Methods:
- Review of historical findings in cellular lifespan studies.
- Analysis of molecular mechanisms of senescence.
- Correlation of telomere length with aging-related diseases.
Main Results:
- Senescence acts as a barrier to oncogenesis but can induce chronic inflammation via senescence-associated secretory phenotype.
- p16, p53, and inflammatory cytokines are established biomarkers for cellular senescence.
- Telomere length in leukocytes correlates with aging-related lifestyle diseases.
Conclusions:
- Cellular senescence is integral to organismal aging.
- Biomarkers of senescence are vital for aging research.
- Future senolytics research holds significant clinical promise for age-related conditions.
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