Clinical significance of long noncoding RNA maternally expressed gene 3 in acute promyelocytic leukemia

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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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Mei Jiang1, Qiufeng Wang2, Ganquan Yu2

  • 1Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University.

International Journal of Laboratory Hematology
|December 29, 2020
PubMed
Abstract

Insights

Maternally expressed gene 3 (MEG3) is significantly increased in acute promyelocytic leukemia (APL). MEG3 serves as a novel diagnostic marker for APL and can evaluate treatment effectiveness.

Area of Science:

  • Hematology
  • Molecular Biology
  • Oncology

Background:

  • Long noncoding RNA maternally expressed gene 3 (MEG3) expression is decreased in acute myeloid leukemia (AML).
  • The role of MEG3 in acute promyelocytic leukemia (APL) is not well understood.
  • This study investigates MEG3 expression and clinical significance in APL.

Purpose of the Study:

  • To investigate MEG3 expression levels in APL.
  • To explore the diagnostic value of MEG3 in APL.
  • To assess the correlation between MEG3 expression and clinicopathological features in APL.

Main Methods:

  • Analysis of 287 AML patients from TCGA and Vizome databases.
  • Development and validation cohorts including APL, other AML subtypes, and controls.
  • Correlation analysis of MEG3 expression with clinicopathological features.
  • Receiver operating characteristic (ROC) curve analysis for diagnostic value.

Main Results:

  • MEG3 expression was significantly increased in APL compared to other AML subtypes and controls.
  • MEG3 expression correlated with age in APL patients.
  • ROC analysis confirmed MEG3's significant diagnostic value for APL.
  • MEG3 expression decreased during follow-up in patients with negative PML/RARα fusion gene.

Conclusions:

  • MEG3 is a novel diagnostic marker for APL.
  • MEG3 can be used to evaluate the curative effect of APL treatment.
  • MEG3 offers a new direction for APL research.
Keywords:
acute promyelocytic leukemiaclinical significancediagnosislncRNAmaternally expressed gene 3

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