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Uncoupling protein gene UCP1-3826A/G, UCP2 Ins/Del and UCP3-55C/T polymorphisms in obese Turkish children

Hasibe Verdi1, Sibel Tulgar Kınık1, H Pınar Baysan-Çebi1

  • 1Departments of Medical Biology, Başkent University Faculty of Medicine, Ankara.

The Turkish Journal of Pediatrics
|December 29, 2020
PubMed

Insights

Genetic variations in mitochondrial uncoupling proteins (UCP1, UCP2, UCP3) are not linked to childhood obesity in Turkish children. However, UCP2 gene variations may affect early insulin response after glucose intake.

Area of Science:

  • Genetics
  • Metabolism
  • Pediatrics

Background:

  • Mitochondrial uncoupling proteins (UCP) 1, 2, and 3 are key regulators of energy metabolism.
  • Previous studies on UCP genotypes and obesity have yielded conflicting results.
  • Investigating UCP gene polymorphisms in relation to obesity is crucial for understanding metabolic health.

Purpose of the Study:

  • To examine the association between common UCP polymorphisms (UCP1-3826A/G, UCP2 Ins/Del, UCP3-55C/T) and obesity in Turkish children.
  • To analyze the relationship of these UCP polymorphisms with metabolic parameters in obese children.

Main Methods:

  • Genotyping of UCP1, UCP2, and UCP3 gene polymorphisms in 189 children (102 obese, 87 controls).
  • Measurement of fasting lipid, glucose, and insulin levels in obese children.
  • Oral glucose tolerance test (OGTT) with glucose and insulin level monitoring in 60 obese children.

Main Results:

  • No significant differences in UCP polymorphism frequencies between obese and non-obese children.
  • UCP1, UCP2, and UCP3 genotypes did not correlate with fasting metabolic parameters.
  • UCP2 Insertion allele carriers showed significantly higher 30-minute insulin levels during OGTT.

Conclusions:

  • UCP1-3826A/G, UCP2 Ins/Del, and UCP3-55C/T polymorphisms are not associated with obesity in Turkish children.
  • The UCP2 Insertion allele may negatively impact early insulin response to glucose loading.
  • Further research is needed to clarify the role of UCP2 in glucose metabolism and insulin sensitivity.
Abstract

Keywords:
OGTTUCPchildrenobesepolymorphism

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