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Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Coagulation01:09

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
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Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Disorders of Hemostasis01:24

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Fetal Circulation01:14

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
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Related Experiment Video

Updated: Nov 24, 2025

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
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Changes in Coagulation During Twin Pregnancies.

Ke Ren1, Yuan Wei1, Rui Qiao2

  • 1Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|December 29, 2020
PubMed
Summary
This summary is machine-generated.

Twin pregnancies show enhanced coagulation compared to singleton pregnancies. Key differences in fibrinogen, activated partial thromboplastin time, prothrombin time, and thrombin time were observed throughout gestation.

Keywords:
coagulationpregnancysingletontwin

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Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
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Last Updated: Nov 24, 2025

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Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Perinatology

Background:

  • Coagulation changes are common during pregnancy.
  • Understanding these changes is crucial for managing pregnancy complications.

Purpose of the Study:

  • To investigate and compare coagulation parameter changes in twin versus singleton pregnancies.
  • To identify specific differences in coagulation profiles between the two pregnancy types.

Main Methods:

  • Retrospective longitudinal analysis of 108 twin and 442 singleton pregnancies.
  • Monitoring of coagulation parameters: fibrinogen (Fib), activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT).

Main Results:

  • Twin pregnancies exhibited higher fibrinogen levels and longer APTT in the third trimester compared to singletons.
  • Shorter PT in twin pregnancies during the first and third trimesters, and shorter TT in the first and second trimesters.
  • Coagulation was found to be significantly more enhanced in twin pregnancies.

Conclusions:

  • Twin pregnancies are characterized by a more pronounced procoagulant state than singleton pregnancies.
  • Specific coagulation parameters differ significantly between twin and singleton gestations, particularly in later trimesters.