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The Jidong Eye Cohort Study: objectives, design, and baseline characteristics
Kai Yang1,2, Lele Cui1,2, Guoyun Zhang1,2
1Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
The Jidong Eye Cohort Study (JECS) investigates visual impairment by examining ocular indicators and their links to cardiovascular and neurological diseases in North China. This research aims to identify risk factors and biomarkers for better understanding and management of these conditions.
Area of Science:
- Ophthalmology
- Epidemiology
- Biomarkers
Background:
- The Jidong Eye Cohort Study (JECS) is a community-based cohort in China.
- It aims to understand the causes and progression of visual impairment.
- The study focuses on ocular indicators in relation to cardio-cerebrovascular and neurological diseases.
Purpose of the Study:
- To describe the objective, design, and baseline characteristics of the JECS.
- To clarify the pathogenesis of visual impairment.
- To investigate ocular indicators in the context of cardiovascular and neurological diseases.
Main Methods:
- Recruited 3377 participants aged 18+ from Jidong communities between August 2019 and January 2020.
- Collected demographic, clinical data, and biological samples via face-to-face interviews.
- Conducted comprehensive ophthalmic examinations including retinal photography and OCT angiography, with annual outcome measurements.
Main Results:
- The cohort consists of 3377 participants (53.6% women, average age 45.0 ± 12.5 years).
- Prevalence of hypertension (25.0%), diabetes (7.7%), hyperglycemia (14.2%), and CVD history (3.0%) were recorded.
- Mean best-corrected visual acuity was 0.1 logMAR, with specific OCT measurements for vascularity and foveal avascular zone.
Conclusions:
- JECS is a significant prospective cohort in North China.
- Rich data will enable identification of risk factors, imaging, and biomarkers for visual impairment.
- The study will evaluate associations between visual impairment and cardiovascular/neurological diseases.
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