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Updated: Nov 23, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Boesenmaxane Diterpenoids from Boesenbergia maxwellii
The S Moe1, Suppisak Chaturonrutsamee2, Samreang Bunteang
1Pharmaceutical Research Laboratory, Biotechnology Research Department, Ministry of Education, Mandalay Division, Kyaukse 05151, Myanmar.
Abstract:
Three new diterpenoids, boesenmaxanes A-C (1-3), with an unprecedented core skeleton consisting of an unusual C-C bond between C-12 and an exo-cyclic methylene C-13, were isolated from the rhizome extracts of Boesenbergia maxwellii. The structures were elucidated by analysis of spectroscopic and X-ray diffraction data. Electronic circular dichroism spectra were used to determine the absolute configuration. All the isolates were evaluated for their cytotoxic effects, anti-HIV activity, and antimicrobial activity. Boesenmaxanes A and C (1 and 3) showed significant inhibitory activity in the syncytium reduction assay, with EC50 values of 55.2 and 27.5 μM, respectively.
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